Question 1

CJ is a 69-year-old male with a history of diabetes, hypertension and hypercholesterolemia. His fasting lipidprofile is TC 530 mg/dL; LDL-C 125; HDL-C 48 mg/dL; and TG 640 mg/dL. His A1c 8.1, calculate creatinineclearance is 65mls/hr, BP 135/80 mm Hg, HR 70 beats /min.His current medications include metformin 1000mg po bid, lisinopril 20mg daily, sitagliptin 50mg bid andatorvastatin 40mg daily.What is the best pharmacological agent to initiate on CJ?

Options :

A : Increase atorvastatin to 80mg

B : Niacin 500mg twice daily

C : Fenofibrate 162mg daily

D : Gemfibrozil 600mg twice daily

E : Fish oil 500mg twice daily

Answer: C

Question 2

Which of the following statements is true regarding Drug-receptor bonds?

Options :

A : Covalent bonds of drugs with receptors are strong and mostly reversible

B : Covalent bonding is much more common than electrostatic bonding in drug-receptor interactions

C : Electrostatic bonds are stronger than covalent bonds

D : Hydrophobic bonds are weak bonds and they are important in the interactions of highly water soluble drugs with the lipids of cell membranes

E : Bond formation of between the acetyl group of aspirin and cyclo-oxygenase enzyme is a covalent bond

Answer: A

Question 3

Which of the following would be most appropriate to treat stenotrophomonas maltophilia?

Options :

A : Meropenem

B : Vancomycin

C : Ciprofloxacin

D : Sulfamethoxazole/trimethoprim

E : Cefepime

Answer: D

Question 4

Which of the following NSAIDs is an Enolic acid derivative?

Options :

A : Ibuprofen

B : Piroxicam

C : Naproxen

D : Oxaprozin

E : Fenoprofen

Answer: B

Question 5

Injectable Sulfamethoxazole/Trimethoprim comes as 400mg/80mg/5ml. Physician requests you to dose aSulfamethoxazole/Trimethoprim intravenously for PCP. You know the dose is 15mg/kg/day (based on TMPcomponent) divided q6h.How many milliliters of Sulfamethoxazole/Trimethoprim of 400mg/80mg/5ml would you need for singledose? Patient weighs 80kg.

Options :

A : 18.75 mL

B : 75 mL

C : 15 mL

D : 50 mL

E : 16.5 mL

Answer: A

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